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KMID : 0387420030140020061
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Korean Society of Oriental Neuropsychiatry
2003 Volume.14 No. 2 p.61 ~ p.78
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Effects of Chengwhabosimtang on depression, anxiety, TH and c-Fos of the brain in the CMS model rats
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Kim Jong-Woo
Kim Eun-Joo
Kim Hyun-Ju
Kim Hyun-Taek
Hwang Wei-Wan
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Abstract
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Objective: This study was designed to assess the protective effects of Chengwhabosimtang on the animal model of depression, chronic mild stress(CMS).
Method: Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Chengwhabosimtang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed Forced swimming test(FST) and Elevated plus maze. Tyrosine hydroxylase(TH) in ventral tegmental area(VTA) and c-Fos in paraventricular nucleus(PVN) were measured.
Results: 1. In FST, CMS-drug group showed significantly decreased immobility behavior. 2. CMS-drug group showed no significantly lower TH level in VTA than CMS-vehicle group. 3. CMS-drug group showed significantly less c-Fos expressed cell bodies in PVN than CMS-vehicle group. 4. In Elevated plus maze, CMS-drug group showed no significantly anxiety.
Conclusion:These results suggest that Chengwhabosimtang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus and dopaminergic neurons in VTA.
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KEYWORD
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Chengwhabosimtang, chronic mild stress, forced swimming test, elevated plus maze, tyrosine hydroxylase, c-Fos
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